Nexturastat A( Nexturastat A )

Catalog No. M11689 CAS No. 1403783-31-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Nexturastat A
Note

Research use only, not for human use.
Brief Description

A potent and selective HDAC6 inhibitor with IC50 of 5 nM.
Description

A potent and selective HDAC6 inhibitor with IC50 of 5 nM; displays >100-fold selectivity over other HDAC isozymes (600-fold relative to the inhibition of HDAC1).
In Vitro

Western Blot Analysis Cell Line:B16 murine melanoma cells Concentration:0-10 μM Incubation Time:24 h Result:Increased the level of acetyl α-tubulin levels in a dose-dependent.Cell Viability Assay Cell Line:RPMI-8226 and U266 cells Concentration:0-40 μM Incubation Time:48 h Result:Impaired multiple myeloma (MM) cells viability in a dose- and time-dependent manner.Apoptosis Analysis Cell Line:RPMI-8226 and U266 cells Concentration:0, 30, 40 μM Incubation Time:48 h Result:Induced cell apoptosis in human MM cells.RT-PCRCell Line:RPMI-8226 and U266 cells Concentration:30 μM Incubation Time:48 h Result:Increased the levels of p21 mRNA in RPMI-8226 and U266 cells.
In Vivo

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Synonyms

Nexturastat A
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC6
Research Area

Cancer
Indication

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CAS Number

1403783-31-2
Formula Weight

341.4042
Molecular Formula

C19H23N3O3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 56 mg/mL
SMILES

O=C(NO)C1=CC=C(CN(CCCC)C(NC2=CC=CC=C2)=O)C=C1
Chemical Name

Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-

1. Bergman JA, et al. J Med Chem. 2012 Nov 26;55(22):9891-9. 2. Miyake Y, et al. Nat Chem Biol. 2016 Sep;12(9):748-54.

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